Amantadine for Parkinson's: Quick Guide

If you or a loved one have Parkinson's disease (PD), you’ve probably heard the name amantadine tossed around. It’s an older drug that started out as an antiviral, but doctors found it helps with the tremors and stiffness that come with PD. Below you’ll get the basics – how it works, how to take it, and what to watch out for.

How Amantadine Helps Parkinson’s Symptoms

Amantadine boosts dopamine activity in the brain, the chemical that slows down in Parkinson’s. By nudging dopamine release and blocking its re‑uptake, the drug can smooth out shaky hands and lessen the “on‑off” swings that many patients feel. Most people notice a modest drop in tremor intensity within a few weeks, and some report better walking stability.

The drug also has mild anti‑cholinergic effects, meaning it can cut down on muscle rigidity. Because of this dual action, doctors sometimes add amantadine to a regimen that already includes levodopa or dopamine agonists. It’s not a cure, but it can make daily tasks feel less like a chore.

Dosage, Safety & Common Side Effects

Typical adult dosing starts at 100 mg once or twice a day. Some clinicians push it up to 200 mg twice daily if tolerated. Always follow the prescription – jumping the dose can raise the risk of side effects.

Speaking of side effects, the most common ones are dry mouth, constipation, and mild dizziness. A small number of users get swelling in the legs or feet (edema), which should be reported right away. Rarely, people develop confusion or hallucinations, especially if they’re older or already on multiple PD meds.

To keep things safe, have your doctor check kidney function before you start – amantadine is cleared through the kidneys. If you have kidney issues, the dose may need to be lowered. Also, avoid alcohol while on the medication because it can amplify dizziness and coordination problems.

When you first begin, keep a simple symptom diary. Note the time you take the pill, any changes in tremor, and any new feelings like nausea or sleepiness. This record helps your doctor fine‑tune the dose faster.

In practice, many patients keep amantadine as a “rescue” drug for sudden flare‑ups of dyskinesia (involuntary movements) caused by levodopa. If you notice those movements getting worse, a short burst of amantadine can sometimes bring them back under control.

Finally, remember that stopping amantadine abruptly can cause a rebound of symptoms. If you need to quit, your doctor will usually taper the dose over a week or two.

Bottom line: amantadine is a useful tool in the Parkinson’s toolbox. It can lessen tremor, improve motor control, and help manage levodopa‑induced dyskinesia. Use it under medical guidance, watch for side effects, and keep track of how you feel. With the right approach, this older drug can make a noticeable difference in everyday life.